GeneXSTEM™ Wharton’s Jelly -Umbilical Cord Tissue Product
GeneXSTEM™1 is derived from Wharton’s Jelly of the non-embryonic umbilical cord and is intended for homologous use. Wharton’s Jelly contains thousands of growth factors, cytokines, long-chain hyaluronic acid, and extracellular vesicles (EV) including exosomes and provides cushioning, protection and structural support within the umbilical cord. It is known for its anti-inflammatory and healing properties. Some patients and providers are choosing human umbilical cord tissue over NSAIDs, corticosteroid injections and platelet rich plasma (PRP) therapy. GeneXSTEM™1 is processed using proprietary methods to preserve the structural integrity of Wharton’s Jelly.
1 GeneXSTEMTM Injectables are minimally manipulated human tissue allografts derived from the Wharton’s Jelly of umbilical cord tissue for homologous use and are not dependent upon the metabolic activity of living cells for its primary function. They comply with the HCT/P 21 CFR 1271 Regulations and Section 361 of the Public Health Service Act.
Advantages of GeneXSTEM™
Derived from the powerful Wharton’s Jelly of the human umbilical cord, known for its growth factors, high molecular weight hyaluronic acid, structural proteins, cytokines, and mesenchymal stem cellular tissue
Provides structural support for tissues and joints
Exciting alternative in regenerative medicine therapy
Can be used widely within orthopaedic, sports medicine and pain management practices
Regenerative Medicine Therapies Comparison
Stem Cells (MSC)
Matrix Components (ECM)
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Characteristics of Wharton’s Jelly
Wharton’s Jelly contains mesenchymal stem cells, growth factors, cytokines and other essential components needed to create life.
- As a mucous connective tissue within the umbilical cord, it consists of high amounts of extracellular matrix components, which are mainly collagen, hyaluronic acid and proteoglycans. 2
- WJ tissue yields the highest concentration of allogeneic MSC’s when compared to adipose tissue. 3
- WJ may promote increased healing. 4
2 Sobolewski, K., Bańkowski, E., Chyczewski, L., & Jaworski, S. (1997). Collagen and Glycosaminoglycans of Wharton’s Jelly. Neonatology, 71(1), 11-21. doi:10.1159/000244392
3 Vangsness, C. T., Sternberg, H., & Harris, L. (2015). Umbilical Cord Tissue Offers the Greatest Number of Harvestable Mesenchymal Stem Cells for Research and Clinical Application: A Literature Review of Different Harvest Sites. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 31(9), 1836-1843. doi:10.1016/j.arthro.2015.03.014
4 Bakhtyar, N., Jeschke, M. G., Mainville, L., Herer, E., & Amini-Nik, S. (2017). Acellular Gelatinous Material of Human Umbilical Cord Enhances Wound Healing: A Candidate Remedy for Deficient Wound Healing. Frontiers in Physiology, 8. doi:10.3389/fphys.2017.00200