BioIntegrate Products

BioIntegrate Products 2018-04-30T20:21:09+00:00

GeneXSTEM Umbilical Cord Tissue Product

GeneXSTEM™1 is derived from Wharton’s Jelly of the non-embryonic umbilical cord and is intended for homologous use. Wharton’s Jelly contains mesenchymal stem cellular products, thousands of growth factors, cytokines, long-chain hyaluronic acid and provides cushioning, protection and structural support within the umbilical cord. It is known for its anti-inflammatory and healing properties. Some patients and providers are choosing human umbilical cord tissue over NSAIDs, corticosteroid injections and platelet rich plasma (PRP) therapy. GeneXSTEM™1 is processed using proprietary methods to preserve the structural integrity of Wharton’s Jelly.

1 GeneXSTEMTM Injectables are minimally manipulated human tissue allografts derived from umbilical cord tissue for homologous use. They comply with the HCT/P 21 CFR 1271 Regulations and Section 361 of the Public Health Service Act.

Advantages of GeneXSTEM

  • Derived from the powerful Wharton’s Jelly of the human umbilical cord, known for its growth factors, high molecular weight hyaluronic acid, structural proteins, cytokines, and mesenchymal stem cellular tissue

  • Provides structural support for tissues and joints

  • Exciting alternative in regenerative medicine therapy

  • Can be used widely within orthopaedic, sports medicine and pain management practices

Regenerative Medicine Therapies Comparison

Mesenchymal
Stem Cells (MSC)
Cytokines Growth Factors Extracellular
Matrix Components (ECM)
Amniotic Fluid XXX XX X
Amniotic Membrane XX XX XXX
Platelet Rich Plasma X XXX
Bone Marrow Aspirate X X XX
Lipoaspirate XX X X
Umbilical Cord XXX XXX XXX XXX

Characteristics of Wharton’s Jelly

Wharton’s Jelly contains mesenchymal stem cells, growth factors, cytokines and other essential components needed to create life.

  • As a mucous connective tissue within the umbilical cord, it consists of high amounts of extracellular matrix components, which are mainly collagen, hyaluronic acid and proteoglycans. 2
  • WJ tissue yields the highest concentration of allogeneic MSC’s when compared to adipose tissue. 3
  • WJ may promote increased healing. 4

2 Sobolewski, K., Bańkowski, E., Chyczewski, L., & Jaworski, S. (1997). Collagen and Glycosaminoglycans of Wharton’s Jelly. Neonatology, 71(1), 11-21. doi:10.1159/000244392

3 Vangsness, C. T., Sternberg, H., & Harris, L. (2015). Umbilical Cord Tissue Offers the Greatest Number of Harvestable Mesenchymal Stem Cells for Research and Clinical Application: A Literature Review of Different Harvest Sites. Arthroscopy: The Journal of Arthroscopic & Related Surgery, 31(9), 1836-1843. doi:10.1016/j.arthro.2015.03.014

4 Bakhtyar, N., Jeschke, M. G., Mainville, L., Herer, E., & Amini-Nik, S. (2017). Acellular Gelatinous Material of Human Umbilical Cord Enhances Wound Healing: A Candidate Remedy for Deficient Wound Healing. Frontiers in Physiology, 8. doi:10.3389/fphys.2017.00200

Umbilical Cord Allograft Suspension

Stem cellular products can provide: tissue repair and regeneration; anti-inflammatory effects and immunomodulation. Recent medical literature also suggests that beneficial effects of stem cells are also through their ability to communicate or signal to other cells, which is known as paracrine actions. “Stem cells can secrete potent combinations of trophic factors that modulate the molecular composition of the environment to evoke responses from resident cells. Based on this new insignt, current research directions include efforts to elucidate augment and harness stem cell paracrine mechanism for tissue regeneration.”1

1. Baraniak, P. R., & Mcdevitt, T. C. (2010). Stem cell paracrine actions and tissue regeneration. Regenerative Medicine, 5(1), 121-143. doi:10.2217/rme.09.74

Available Dosage

GeneXSTEM  products are currently available in 1 ml aliquots.

Logistics

GeneXSTEM  umbilical cord tissue allograft is shipped overnight frozen directly to your medical practice.

FDA Guidance

GeneXSTEM is processed from donated human tissue from full term deliveries and is regulated as a human cell, tissue, or cellular or tissue-based product (HCT/P) under 21 CFR Part 1271 and Section 361 of the Public Health Service Act. It is intended for homologous use and is minimally manipulated. The FDA defines Homologous use to mean “the repair, reconstruction, replacement, or supplementation of the recipient’s cells or tissues with an HCT/P that performs the same basic function or functions in the recipient as in the donor”.

The Three Steps To Healing

Remove the Inflammation

Cytokines are known to be anti-inflammatory and communicate to your body to reduce the inflammation

Lessen the Pain

After the inflammation reduces, your pain lessens, helping your body return to its normal state

Regeneration and Healing

The growth factors fuel and stimulate the body’s natural ability to heal, repair and regenerate

Discover The Next Wave Of Regenerative Medicine

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