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Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy

By | 2018-04-26T19:08:25+00:00 April 5th, 2018|

The paper presents current evidence on the properties of human umbilical cord-derived mesenchymal stem cells, including origin, proliferative potential, plasticity, stability of karyotype and phenotype, transcriptome, secretome, and immunomodulatory activity. A review of preclinical studies and clinical trials using this cell type is performed. Prospects for the use of mesenchymal stem cells, derived [...]

Intra-articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee

By | 2018-04-26T19:09:45+00:00 April 5th, 2018|

A 2-Year Follow-up Study Background: The intra-articular injection of mesenchymal stem cells (MSCs) into the knee has shown a potential for the treatment of generalized cartilage loss in osteoarthritis (OA). However, there have been few midterm reports with clinical and structural outcomes. Purpose: To assess the midterm safety and efficacy of an intra-articular [...]

Mesenchymal Stem Cells in the Wharton’s Jelly of the Human Umbilical Cord

By | 2018-04-26T19:10:37+00:00 April 5th, 2018|

Abstract:  The Wharton’s jelly of the umbilical cord contains mucoid connective tissue and fibroblast-like cells. Using flow cytometric analysis, we found that mesenchymal cells isolated from the umbilical cord express matrix receptors (CD44, CD105) and integrin markers (CD29, CD51) but not hematopoietic lineage markers (CD34, CD45). Interestingly, these cells also express significant amounts [...]

A Comprehensive Review of Stem-Cell Therapy

By | 2018-04-26T19:11:06+00:00 April 5th, 2018|

Abstract: » Regenerative orthopaedics has been used as a biological alternative to conventional therapy and surgical intervention for treating musculoskeletal conditions associated with limited therapeutic options. » Orthopaedic investigators have shown promising early clinical results by developing cell-based approaches to regenerate injured cartilage, tendon, ligaments, and bone. » Despite continued research, issues regarding [...]

Umbilical Cord Tissue Offers the Greatest Number of Harvestable Mesenchymal Stem Cells for Research and Clinical Application: A Literature Review of Different Harvest Sites

By | 2018-04-26T19:12:24+00:00 April 5th, 2018|

Purpose: Recent years have seen dramatic increases in the techniques used to harvest and isolate human mesenchymal stem cells. As the potential therapeutic aspects of these cells further develop, informative data on the differences in yields between tissue harvest sites and methods will become increasingly valuable. We collected and compared data on cell yields [...]

Wharton’s Jelly Derived Mesenchymal Stem Cells: Future of Regenerative Medicine? Recent Findings and Clinical Significance

By | 2018-04-26T19:12:56+00:00 April 5th, 2018|

Around 5 million annual births in EU and 131 million worldwide give a unique opportunity to collect lifesaving Wharton’s jelly derived mesenchymal stem cells (WJ-MSC). Evidences that these cells possess therapeutic properties are constantly accumulating. Collection ofWJ-MSC is done at the time of delivery and it is easy and devoid of side effects [...]

The Placenta: Applications in Orthopaedic Sports Medicine.

By | 2018-04-05T18:23:09+00:00 June 30th, 2017|

Abstract   BACKGROUND: Placenta has a long history of use for treating burns and wounds. It is a rich source of collagen and other extracellular matrix proteins, tissue reparative growth factors, and stem cells, including mesenchymal stem cells (MSCs). Recent data show its therapeutic potential for orthopaedic sports medicine indications. PURPOSE: To provide [...]